Cushing's syndrome

Cushing's syndrome is a condition caused by having too much of a hormone called cortisol in your body. It can be serious if it's not treated. See a GP if you have symptoms of Cushing's syndrome, especially if you're taking steroids, (see symptoms below).

Who gets it and why

Cushing's syndrome is uncommon. It mostly affects people who have been taking steroid medicine, especially steroid tablets, for a long time.

Steroids contain a man-made version of cortisol.

Very rarely, it can be caused by the body producing too much cortisol. This is usually due to:

  • a growth (tumour) in the pituitary gland in the brain
  • a tumour in one of the adrenal glands above the kidneys

The tumours are usually non-cancerous (benign). They're most common in young women.

Symptoms of Cushing's syndrome

Symptoms of Cushing's syndrome can begin suddenly or gradually. They tend to get slowly worse if not treated.

One of the main signs is weight gain and more body fat, such as:

  • increased fat on your chest and tummy, but slim arms and legs
  • a build-up of fat on the back of your neck and shoulders – known as a ’buffalo hump’
  • a red, puffy, rounded face

Other symptoms include:

  • skin that bruises easily
  • large purple stretch marks
  • weakness in your upper arms and thighs
  • a low libido and fertility problems
  • depression and mood swings

Cushing's syndrome can also cause high blood pressure, which can be serious if not treated. It also can cause high glucose (sugar) levels in your blood, causing symptoms of diabetes.

When to get medical advice

You should see your GP if you have symptoms of Cushing's syndrome, especially if you're taking steroids.

Don't stop taking your medicine without getting medical advice.

Lots of things can cause similar symptoms to Cushing's syndrome. It's a good idea to get your symptoms checked to find out what the problem is.

Your doctor may suspect Cushing's syndrome if you have typical symptoms and are taking steroid medicine.

If you're not taking steroids, it can be difficult to diagnose because the symptoms can be similar to other conditions.

If Cushing's syndrome is suspected, the amount of cortisol in your body can be measured in your:

  • urine
  • blood
  • saliva

If these tests show a high level of cortisol, you may be referred to a specialist in hormone conditions (endocrinologist). This is to confirm or rule out if you have Cushing's syndrome.

You may also need other tests or scans to find out the cause.

Treatment for Cushing's syndrome

Cushing's syndrome usually gets better with treatment. Although it might take a long time to recover completely.

Treatment depends on what's causing it.

If it's caused by taking steroids:

  • your steroid dose will be gradually reduced or stopped

If it's caused by a tumour, treatment may include:

  • surgery to remove the tumour
  • radiotherapy to destroy the tumour
  • medicines to reduce the effect of cortisol on your body

Speak to your doctor about the benefits and risks of the different treatment options.

The information on this page has been adapted from original content from the NHS website.

For further information see terms and conditions.

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