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    1. Home
    2. Health and wellbeing
    3. Illnesses and conditions
    4. A to Z

    Soft tissue sarcomas

    Soft tissue sarcomas are a group of rare cancers. These affect the tissues that connect, support and surround other body structures and organs. See your GP if you have a worrying lump. Although it's much more likely you have a non-cancerous condition, it's important to get your symptoms checked out.

    About soft tissue sarcomas

    Tissues that can be affected by soft tissue sarcomas include:

    • fat
    • muscle
    • blood vessels
    • deep skin tissues
    • tendons and ligaments

    Bone sarcomas are covered separately.

    Soft tissue sarcomas can develop in almost any part of the body, including the legs, arms and torso.

    Symptoms of soft tissue sarcomas

    Soft tissue sarcomas often have no obvious symptoms in the early stages.

    They can cause symptoms as they get bigger or spread. The symptoms depend on where the cancer develops.

    For example:

    • cancer in the tissue under the skin may cause a soft, painless lump that can't easily be moved around and gets bigger over time
    • cancer near the stomach may cause tummy (abdominal) pain, a persistent feeling of fullness and constipation
    • cancer near the lungs may cause a cough or breathlessness

    When to see your GP

    You should see your GP if you have a worrying lump. This is particularly if you have:

    • a lump that's getting bigger over time
    • a lump the size of a golf ball or larger
    • any other troublesome symptoms

    Although it's much more likely you have a non-cancerous condition, such as a cyst (fluid under the skin) or lipoma (fatty lump), it's important to get your symptoms checked out.

    If your GP is concerned there's a possibility you have cancer, they'll refer you for a number of hospital tests.

    A diagnosis of a soft tissue sarcoma will usually be made by a hospital specialist. It will be based on your symptoms, a physical examination, and the results of tests.

    Causes of soft tissue sarcomas

    Cancer occurs when cells multiply uncontrollably, forming growths called tumours.

    In the majority of soft tissue sarcomas it's unclear what causes this to happen. But there are a number of things known to increase the risk.

    Age

    Soft tissue sarcomas can occur at any age, including in children, but are more common in middle-aged, or elderly people. Your risk increases as you get older.

    Genetic conditions

    Some genetic conditions, such as neurofibromatosis type 1 and retinoblastoma, are associated with an increased risk of soft tissue sarcomas.

    Radiotherapy

    Some people, who have previously had radiotherapy for another type of cancer, go on to develop a soft tissue sarcoma, often many years later.

    Exposure to chemicals

    Exposure to certain chemicals, including vinyl chloride, dioxins and phenoxyacetic herbicides, has been associated with increased rates of soft tissue sarcomas.

    Kaposi's sarcoma is a very rare sarcoma, caused by a virus known as the human herpesvirus type 8 (HHV-8), infecting someone with a weakened immune system (such as people with HIV).

    Treatment for soft tissue sarcomas

    If you are diagnosed with a soft tissue sarcoma, the health professional looking after your care will discuss treatment options with you.

    The best treatment will depend on:

    • where the cancer developed
    • the type of sarcoma it is
    • how far it has spread
    • your age
    • your general health

    The main treatments are:

    • surgery to remove any tumour
    • radiotherapy – where high-energy radiation is used to kill cancer cells
    • chemotherapy and other medications to kill cancer cells

    Types of soft tissue sarcoma

    There are many different types of soft tissue sarcoma, depending on where in the body it develops.

    Examples include:

    • leiomyosarcoma – develops in muscle tissue
    • liposarcoma – develops in fat tissue
    • angiosarcoma – develops in the cells of the blood or lymph glands
    • gastrointestinal stromal tumours (GISTs) – develop in the connective tissues that support the organs of the digestive system

    Outlook for soft tissue sarcomas

    The outlook for a soft tissue sarcoma mostly depends on:

    • the type of sarcoma it is
    • how likely it is to spread (the grade)
    • how far it has already spread (the stage) by the time it's diagnosed

    If it's detected at an early stage, or is a low grade tumour and it can be removed during surgery, a cure is usually possible.

    Larger, higher grade tumours have a greater risk of coming back or spreading.

    After initial treatment, you'll need regular check-ups to look for any signs the cancer has come back.

    You may also need physiotherapy and occupational therapy to help you manage any physical difficulty resulting from surgery.

    A cure isn't usually possible if a soft tissue sarcoma is only detected when it has already spread to other parts of the body. Although treatment can help slow the spread of the cancer and control your symptoms.

    • Soft tissue sarcomas

    More useful links

    • Northern Ireland Cancer Network
    • Action Cancer
    • Marie Curie
    • Cancer Focus Northern Ireland
    • Macmillan Cancer Support
    • Cancer Research UK

    The information on this page has been adapted from original content from the NHS website.

    For further information see terms and conditions.

    Health conditions A to Z

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